Tumor-suppressor genes versus Proto-oncogenes

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Tumor-suppressor genes versus Proto-oncogenes.

This is a library-research topic in which you are required to provide your sources. Mutations in tumor suppressor genes can contribute to or cause cancer, just as mutations in proto-oncogenes can also contribute to or cause cancer. However, tumor suppressor genes are very different from proto-oncogenes.

(a) Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased risk of cancer.
(b) Explain why a loss-of-function mutation to a tumor suppressor gene may be associated with increased risk of cancer.

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References:

Khan Academy, No date given. Apoptosis

, https://www.khanacademy.org/science/biology/cellular-molecular-biology/stem-cells-and-cancer/v/apoptosis
Lindsey Valich, April 19, 2018. Scientists discover gene controlling genetic recombination rates. http://www.rochester.edu/newscenter/genetic-recombination-selfish-dna-may-help-explain-differences-in-fruit-flies-312422/

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